I don't remember if it's been covered yet, but formation subs in your roster management screen that stick every game and, obviously, assigning defensive match ups.
I'd also like to see more of an emphasis on expanding CFM. Add in more production value. An in season radio show like the old Tony Bruno show or a Sportscenter highlight show. Maybe a draft preview show. Also more hype for the Super Bowl and more pomp and circumstance for the winner so it means more than just a title.
I'd also like to see a true Sperstar mode return where you can create a player or choose an existing player and build him up, request trades, have career earnings with maybe an ability to buy houses and card and maybe invest in businesses. Something that grabs you and makes you want to keep playing and evolving your player.
The most important thing, though, is the CPU AI. The best CFM and Superstar mode on the planet means nothing if the CPU AI is trash. Unfortunately, right now, the CPU AI is very poor and it ruins the solo experience which I think turns a lot of people off from the series.